This the continuation of my other post, that tackles the proton pump inhibitor with the main action is to decrease the gastric acid secretion thus helps in reducing ulcer progress. The other one is the cytoprotective medications with the primary action is to protect the mucosal lining thus eliminates gastric irritation.
Proton (Gastric Acid) Pump Inhibitor
Omeprazole ( Prilosec ) - decreases gastric acid secretion by slowing the hydrogen-potassium-adenosine triphosphate (H+,K+-ATPase) pump on the surface of the parietal cells. The patient should be infromed the long term use may cause ulcer or gastric tumors and bacterial invasion so that they are aware of this.
Cytoprotective Medications
Misoprostol( Cytotec ) - a synthetic prostaglandin, protects the gastric mucosa from ulcerogenic agents. It increases mucus production and bicarbonate levels to reduce acidity that may cause ulcer progresses. It is also used as preventive method inpatients using NSAIDs. It is advisable to take the drug with food to reduce gastrointestinal irritation. The patient should be inform about the side effects such as that might cause diarrhea and cramping include uterine cramping. Not advisable to take during pregnancy and please tell your doctor so abortion may prevented.
Sucrafate ( Carafate ) - in the presence of gastric acid, sucralfate creates a viscous protective substance, forming a protective layer at the site of the ulcer, and prevents digestion by pepsin. May cause constipation or nausea so the patient should be inform. Approved to use it for duodenal ulcers as a drug of choice, not in gastric ulcers.
Proton (Gastric Acid) Pump Inhibitor
Omeprazole ( Prilosec ) - decreases gastric acid secretion by slowing the hydrogen-potassium-adenosine triphosphate (H+,K+-ATPase) pump on the surface of the parietal cells. The patient should be infromed the long term use may cause ulcer or gastric tumors and bacterial invasion so that they are aware of this.
Cytoprotective Medications
Misoprostol( Cytotec ) - a synthetic prostaglandin, protects the gastric mucosa from ulcerogenic agents. It increases mucus production and bicarbonate levels to reduce acidity that may cause ulcer progresses. It is also used as preventive method inpatients using NSAIDs. It is advisable to take the drug with food to reduce gastrointestinal irritation. The patient should be inform about the side effects such as that might cause diarrhea and cramping include uterine cramping. Not advisable to take during pregnancy and please tell your doctor so abortion may prevented.
Sucrafate ( Carafate ) - in the presence of gastric acid, sucralfate creates a viscous protective substance, forming a protective layer at the site of the ulcer, and prevents digestion by pepsin. May cause constipation or nausea so the patient should be inform. Approved to use it for duodenal ulcers as a drug of choice, not in gastric ulcers.
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