Let me start with asking a question what is peptic ulcer? what is the cause of it? how it progresses? what are the things need to be considered? This questions are necessary in finding the facts about this specific disease. I hope that this will help in knowing PUD and understanding it so that it will be prevented. Education is the best prevention.
A peptic ulcer is an excavation (hollowed-out area) formed in the mucosal wall of the stomach, the pylorus (opening between stomach and duodenum ), the duodenum (first part of the small intestine), or the esophagus. A peptic ulcer is frequently referred as to gastric, duodenal, or esophageal ulcer depending on its location, or as peptic ulcer disease. It is caused by the erosion of a circumscribed area of mucous membrane. This erosion may extend as deeply as the muscle layers or through the muscle to the peritoneum. Peptic ulcers are more likely to be in the duodenum than in the stomach. As a rule they occur alone, but they may occur in multiples. Chronic gastric ulcers tend to occur in the lesser curvature of the stomach, near the pylorus.
Zollinger-Ellsion syndrome (ZES), which consists of severe peptic ulcers, extreme gastric hyperacidity, and gastrin secreting benign or malignant tumors of the pancreas, is a type of peptic ulceration. Stress ulcers, which are clinically different from peptic ulcers, are ulceration in mucosa that can occur in the gastroduodenal area. Both of these conditions are discussed with peptic ulcers.
The gram negative bacteria H. pylori is present in 70% of patients with gastric ulcers and 95% of patients with duodenal ulcer. It is not associated with esophageal ulcers. Peptic ulcers treated with antibiotics to eradicate H. pylori that causes ulcer, have a 10% recurrence rate; those not treated for H. pylori have a 95% recurrence rate. The disease occurs with the greatest frequency in people between ages of 40 to 60 years. It is relatively uncommon in women of childbearing age,but it has been observed in children and even infants.
In the past, stress and anxiety were thought to be the causative factors in ulcer occurrence. Ulcers do seem develop more commonly in people who are tense, but whether this is a contributing factor to the condition is uncertain. The presence of the excessive secretion of hydrochloric acid in the stomach may contribute to the formation of gastric ulcers, and stress may be associated with an increase in hydrocloric acid secretion. The ingestion of milk and caffeinated beverages, smoking and the alcohol may also increase hydrochloric acid secretion.
A peptic ulcer is an excavation (hollowed-out area) formed in the mucosal wall of the stomach, the pylorus (opening between stomach and duodenum ), the duodenum (first part of the small intestine), or the esophagus. A peptic ulcer is frequently referred as to gastric, duodenal, or esophageal ulcer depending on its location, or as peptic ulcer disease. It is caused by the erosion of a circumscribed area of mucous membrane. This erosion may extend as deeply as the muscle layers or through the muscle to the peritoneum. Peptic ulcers are more likely to be in the duodenum than in the stomach. As a rule they occur alone, but they may occur in multiples. Chronic gastric ulcers tend to occur in the lesser curvature of the stomach, near the pylorus.
Zollinger-Ellsion syndrome (ZES), which consists of severe peptic ulcers, extreme gastric hyperacidity, and gastrin secreting benign or malignant tumors of the pancreas, is a type of peptic ulceration. Stress ulcers, which are clinically different from peptic ulcers, are ulceration in mucosa that can occur in the gastroduodenal area. Both of these conditions are discussed with peptic ulcers.
The gram negative bacteria H. pylori is present in 70% of patients with gastric ulcers and 95% of patients with duodenal ulcer. It is not associated with esophageal ulcers. Peptic ulcers treated with antibiotics to eradicate H. pylori that causes ulcer, have a 10% recurrence rate; those not treated for H. pylori have a 95% recurrence rate. The disease occurs with the greatest frequency in people between ages of 40 to 60 years. It is relatively uncommon in women of childbearing age,but it has been observed in children and even infants.
In the past, stress and anxiety were thought to be the causative factors in ulcer occurrence. Ulcers do seem develop more commonly in people who are tense, but whether this is a contributing factor to the condition is uncertain. The presence of the excessive secretion of hydrochloric acid in the stomach may contribute to the formation of gastric ulcers, and stress may be associated with an increase in hydrocloric acid secretion. The ingestion of milk and caffeinated beverages, smoking and the alcohol may also increase hydrochloric acid secretion.
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