This are the drug of choice PUD. My last post was all about the drug therapy with its primary concern was Antibiotics and Bismuth salts. And now let us know the other drug classification that helps in treating PUD. The another class is the Histamine (H2) Receptor Antagonists and its primary action is to block the H2 receptor.
Cimetidine ( Tagamet ) - inhibits acid ( cause of ulcer ) secretion by blocking the action of histamine on the histamine receptors of the parietal cell in the stomach. This drug is the least expensive of the H2 receptor antagonists thus it more affordable to the public. Because it is least expensive their must be a bigger side effects compared to other drugs. The patient should be warn the this may cause confusion, agitation or coma in the elderly. To those with renal or hepatic insufficiency, it is advisable to tell the doctor about this so that they will be aware of the situation and change their drug of choice. Long term use may cause gynecomastia or enlarged breast in male, impotence to both sexes and diarrhea. The patient should be inform about this matter.
Ranitidine ( Zantac ) - inhibits acid secretion by blocking the action of histamine on the histamine receptors of the parietal cell in the stomach. It has prolonged drug half-life in patients with renal and hepatic insufficiency. Causes fewer side effects than cimetidine. It is rarely causes constipation, diarrhea, dizziness and depression
Famotidine ( Pepcid ) - inhibits acid secretion by blocking the action of histamine on the histamine receptors of the parietal cell in the stomach. Best choice for critically ill patients because it is known to have least risk of interaction with drugs other than cimetidine. It is unclear if other H2 receptor antagonists are as safe as famotodine. It does not alter drug metabolism in the liver. It has prolonged drug half-life in patients with renal and hepatic insufficiency. It can be use for short term relief for gasttroesophageal reflux or heart burn. The good thing is it rarely causes constipation or diarrhea.
Nizantidine ( Axid ) -inhibits acid secretion by blocking the action of histamine on the histamine receptors of the parietal cell in the stomach. Most doctors usually used it for duodenal ulcers as a drug of choice. It has prolonged drug half-life in patients with renal and hepatic insufficiency. Another good thing is it rarely causes sweating , increased liver enzymes, nausea and urticaria (skin irritation).
Cimetidine ( Tagamet ) - inhibits acid ( cause of ulcer ) secretion by blocking the action of histamine on the histamine receptors of the parietal cell in the stomach. This drug is the least expensive of the H2 receptor antagonists thus it more affordable to the public. Because it is least expensive their must be a bigger side effects compared to other drugs. The patient should be warn the this may cause confusion, agitation or coma in the elderly. To those with renal or hepatic insufficiency, it is advisable to tell the doctor about this so that they will be aware of the situation and change their drug of choice. Long term use may cause gynecomastia or enlarged breast in male, impotence to both sexes and diarrhea. The patient should be inform about this matter.
Ranitidine ( Zantac ) - inhibits acid secretion by blocking the action of histamine on the histamine receptors of the parietal cell in the stomach. It has prolonged drug half-life in patients with renal and hepatic insufficiency. Causes fewer side effects than cimetidine. It is rarely causes constipation, diarrhea, dizziness and depression
Famotidine ( Pepcid ) - inhibits acid secretion by blocking the action of histamine on the histamine receptors of the parietal cell in the stomach. Best choice for critically ill patients because it is known to have least risk of interaction with drugs other than cimetidine. It is unclear if other H2 receptor antagonists are as safe as famotodine. It does not alter drug metabolism in the liver. It has prolonged drug half-life in patients with renal and hepatic insufficiency. It can be use for short term relief for gasttroesophageal reflux or heart burn. The good thing is it rarely causes constipation or diarrhea.
Nizantidine ( Axid ) -inhibits acid secretion by blocking the action of histamine on the histamine receptors of the parietal cell in the stomach. Most doctors usually used it for duodenal ulcers as a drug of choice. It has prolonged drug half-life in patients with renal and hepatic insufficiency. Another good thing is it rarely causes sweating , increased liver enzymes, nausea and urticaria (skin irritation).
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